A. T. Nelson

Beneficial metabolic effects of PAHSAs depend on the gut microbiota in diet-induced obese mice

This study shows that PAHSAs improve insulin sensitivity in diet-induced obese mice via the gut microbiota, with sex-specific effects observed.

Molecular underpinnings of ssDNA specificity by Rep HUH endonucleases and implications for HUH-tag multiplexing and engineering

The paper investigates the molecular mechanism of ssDNA specificity by HUH-endonucleases and demonstrates how this can be engineered for multiplexed HUH-tagging and bioconjugation.

Student-focused development of a next-generation centrifuge force microscope

This paper describes the development of an affordable centrifuge force microscope (CFM) by students, emphasizing educational value and hands-on research experience.

Chemical Impacts of the Microbiome Across Scales Reveal Novel Conjugated Bile Acids

The paper identifies novel conjugated bile acids produced by the microbiome in mice and humans using mass spectrometry and a murine 3D model.

Bifunctional Substrate Activation via an Arginine Residue Drives Catalysis in Chalcone Isomerases

The paper elucidates the catalytic mechanism of chalcone isomerases, showing how an arginine residue activates substrates via Bronsted and Lewis acid interactions, and highlights structural differences between type-1 and type-2 enzymes.