Lower shear stress exacerbates atherosclerosis by inducing the generation of neutrophil extracellular traps via Piezo1-mediated mechanosensation
Y. Zhu, T. Wang, Z. Wang, X. Chen, L. Wang, R. Niu, Z. Sun, C. Zhang, Y. Luo, Y. Hu, W. Gu
This study shows that lower shear stress promotes neutrophil extracellular traps (NETs) formation, which worsens atherosclerosis by damaging endothelial cells through Piezo1-mediated mechanosensation.
bioRxiv · Feb 19, 2023 · PreprintCell Biology