Author

R. Noble

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 1 Evolutionary Biology· 1

Signature Assays, Organisms & Methods

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Approach:statistical model· 2 Research Focus:cancer & tumor microenvironment· 1 Research Focus:drug response / drug discovery· 1 Organism:human· 1 Assay:whole-genome sequencing· 1

Frequent Co-Authors

N. Beerenwinkel· 2 shared D. Burri· 1 shared J. Cairns· 1 shared J. N. Kather· 1 shared T. Kuosmanen· 1 shared T. Mononen· 1 shared V. Mustonen· 1 shared

Activity by Year

2019-2020 · peak 1/yr

Co-Author Collaboration Network

7 top collaborators · 13 mutual co-author links

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2 shared papersEvolutionary Biology

N. Beerenwinkel

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2 papers

Recent·Most cited

Drug-induced resistance evolution necessitates less aggressive treatment

T. Kuosmanen, J. Cairns, R. Noble, N. Beerenwinkel, T. Mononen, V. Mustonen

This paper shows that aggressive drug treatments can increase resistance evolution by altering mutation rates, and proposes an optimal treatment strategy that minimizes resistance risk.

bioRxiv · Oct 7, 2020Evolutionary Biology

Spatial structure governs the mode of tumour evolution

R. Noble, D. Burri, J. N. Kather, N. Beerenwinkel

The paper shows that tumour architecture determines evolutionary patterns, identifying four onco-evolutionary modes based on spatial structure and cell dispersal.

bioRxiv · Apr 13, 2019Cancer Biology