Author

T. Mononen

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Evolutionary Biology· 2

Signature Assays, Organisms & Methods

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Research Focus:drug response / drug discovery· 2 Approach:experimental assay· 1 Research Focus:host-pathogen & immune response· 1 Approach:statistical model· 1

Frequent Co-Authors

J. Cairns· 2 shared V. Mustonen· 2 shared F. Borse· 1 shared N. Beerenwinkel· 1 shared R. Noble· 1 shared T. Hiltunen· 1 shared T. Kuosmanen· 1 shared

Activity by Year

2020-2020 · peak 2/yr

Co-Author Collaboration Network

7 top collaborators · 15 mutual co-author links

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2 shared papersEvolutionary Biology

J. Cairns

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2 papers

Recent·Most cited

Strong selective environments determine evolutionary outcome in time-dependent fitness seascapes

J. Cairns, F. Borse, T. Mononen, T. Hiltunen, V. Mustonen

This study shows that strong selective agents drive evolutionary outcomes in time-dependent fitness seascapes, with implications for predicting and mitigating drug resistance.

bioRxiv · Dec 1, 2020Evolutionary Biology

Drug-induced resistance evolution necessitates less aggressive treatment

T. Kuosmanen, J. Cairns, R. Noble, N. Beerenwinkel, T. Mononen, V. Mustonen

This paper shows that aggressive drug treatments can increase resistance evolution by altering mutation rates, and proposes an optimal treatment strategy that minimizes resistance risk.

bioRxiv · Oct 7, 2020Evolutionary Biology