Side chain to main chain hydrogen bonds stabilize a polyglutamine helix in the activation domain of a transcription factor
A. Escobedo, B. Topal, M. B. A. Kunze, J. Aranda, G. Chiesa, D. Mungianu, G. Bernardo-Seisedos, B. Eftekharzadeh, M. Gairi, R. Pieratelli, I. Felli, T. Diercks, O. Millet, J. Garcia, M. Orozco, , X. Salvatella
This study investigates how polyglutamine tract length affects the structure and function of the androgen receptor, revealing hydrogen bonds that stabilize a helical conformation linked to transcriptional activity and disease.
bioRxiv · Feb 28, 2019Biophysics