Author

B. Topal

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biophysics· 2 Immunology· 1 Pharmacology & Toxicology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Organism:human· 2 Assay:protein structure· 2 Assay:bulk RNA-seq· 1 Research Focus:cell signaling & trafficking· 1 Research Focus:chromatin & epigenetic regulation· 1 Approach:deep learning· 1 Research Focus:differential expression· 1

Frequent Co-Authors

A. Escobedo· 2 shared J. Aranda· 2 shared J. Garcia· 2 shared M. Orozco· 2 shared O. Millet· 2 shared R. Crehuet· 2 shared T. Diercks· 2 shared X. Salvatella· 2 shared

Activity by Year

2019-2024 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 29 mutual co-author links

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2 shared papersBiophysics

A. Escobedo

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

Impact of juglone on oral carcinogenesis induced by 4-nitroquinoline-1-oxide (4NQO) in rat model

O. Topal, B. Topal, Y. Bas, B. Ongan, G. Sadi, E. Aslan, B. Demirciler Yavas, M. B. Pektas

This study investigates juglone's effects on oral carcinogenesis in rats, finding it induces apoptosis and suppresses antiapoptotic factors, with synergistic effects when combined with 4-NQO.

bioRxiv · Jan 26, 2024 · PreprintPharmacology & Toxicology

A glutamine-based single α-helix scaffold to target globular proteins

A. Escobedo, J. G. Piccirillo, J. Aranda, T. Diercks, B. Topal, M. Biesaga, L. Staby, B. B. Kragelund, J. Garcia, O. Millet, M. Orozco, M. Coles, R. Crehuet, X. Salvatella

This paper introduces a method to design peptides that fold into single α-helices using glutamine side chain to main chain hydrogen bonds, enabling targeted interactions with globular proteins.

bioRxiv · May 6, 2022Biophysics

Macrophage Scavenger Receptor 1 mediates lipid-induced inflammation in non-alcoholic fatty liver disease

O. Govaere, S. K. Petersen, N. Martinez-Lopez, J. Wouters, M. Van Haele, R. M. Mancina, O. Jamialahmadi, O. Bilkei-Gorzo, P. B. Lassen, R. Darlay, J. Peltier, J. M. Palmer, R. Younes, D. Tiniakos, G. P. Aithal, , A. Hartlova

This study identifies MSR1 as a key mediator of lipid-induced inflammation in NAFLD, showing its role in macrophage activation and potential as a therapeutic target.

bioRxiv · Feb 1, 2020Immunology

Side chain to main chain hydrogen bonds stabilize a polyglutamine helix in the activation domain of a transcription factor

A. Escobedo, B. Topal, M. B. A. Kunze, J. Aranda, G. Chiesa, D. Mungianu, G. Bernardo-Seisedos, B. Eftekharzadeh, M. Gairi, R. Pieratelli, I. Felli, T. Diercks, O. Millet, J. Garcia, M. Orozco, , X. Salvatella

This study investigates how polyglutamine tract length affects the structure and function of the androgen receptor, revealing hydrogen bonds that stabilize a helical conformation linked to transcriptional activity and disease.

bioRxiv · Feb 28, 2019Biophysics