X. Salvatella

Measuring age-dependent viscoelastic properties of organelles, cells and organisms via Time-Shared Optical TweezerMicrorheology

This paper introduces a time-shared optical tweezer microrheology method to measure age-dependent viscoelastic properties of biological materials, demonstrating its application in biomolecular condensates, zebrafish cells, and C. elegans.

Kinetic stabilization of translation-repression condensates by a neuron-specific microexon

The paper shows that a neuron-specific microexon in CPEB4 stabilizes translation-repression condensates by competing with aggregation, enabling reversible regulation of gene expression in neurons.

GEMC1 and MCIDAS interactions with SWI/SNF complexes regulate the multiciliated cell-specific transcriptional program

This study identifies distinct interactions of GEMC1 and MCIDAS with SWI/SNF subcomplexes in multiciliated cell differentiation and shows that these interactions are required for MCC-specific transcriptional regulation.

Rational optimization of a transcription factor activation domain inhibitor

This study optimizes a small molecule inhibitor targeting the aromatic-rich activation domain of the androgen receptor, showing improved affinity and antitumorigenic effects in prostate cancer models.

A rigidity phase transition of Stomatin condensates governs a switch from transport to mechanotransduction

The paper shows that MEC-2 Stomatin undergoes a rigidity phase transition in C. elegans, switching between transport and mechanotransduction functions.

A glutamine-based single α-helix scaffold to target globular proteins

This paper introduces a method to design peptides that fold into single α-helices using glutamine side chain to main chain hydrogen bonds, enabling targeted interactions with globular proteins.

Sorting of secretory proteins at the trans-Golgi network by human TGN46

This study identifies TGN46 as a receptor for sorting secretory cargo protein PAUF into TGN-to-plasma membrane carriers, showing its lumenal domain is essential for cargo sorting.

Small Molecules Targeting the Disordered Transactivation Domain of the Androgen Receptor Induce the Formation of Collapsed Helical States

This paper uses molecular dynamics simulations to study how small molecules bind to the disordered AR-NTD, revealing structural mechanisms that explain their potency and provide insights for drug design.

Mitochondrial cytochrome c liberates the nucleophosmin-sequestered ARF tumor suppressor in the nucleolus

This study identifies mitochondrial cytochrome c as a factor that releases ARF tumor suppressor from NPM sequestration in the nucleolus upon DNA damage.

Bayesian-Maximum-Entropy reweighting of IDPs ensembles based on NMR chemical shifts

The paper introduces a Bayesian-Maximum-Entropy method to reweight IDP ensembles using NMR chemical shifts, showing it provides consistent results even when other fitting assessment methods fail.

Side chain to main chain hydrogen bonds stabilize a polyglutamine helix in the activation domain of a transcription factor

This study investigates how polyglutamine tract length affects the structure and function of the androgen receptor, revealing hydrogen bonds that stabilize a helical conformation linked to transcriptional activity and disease.