CRISPR-Cas9 knockdown of ESR1 in preoptic GABA-kisspeptin neurons suppresses the preovulatory surge and estrous cycles in female mice
J. Clarkson, S. H. Yip, R. Porteous, A. Kauff, A. K. Heather, A. E. Herbison
This study shows that knocking down ESR1 in GABA-kisspeptin neurons of the RP3V in female mice suppresses the preovulatory LH surge and estrous cycles.
bioRxiv · Jul 20, 2023 · PreprintPhysiology