The resting and ligand-bound states of the membrane-embedded human T-cell receptor-CD3 complex
R. Q. Notti, F. Yi, S. Heissel, M. W. Bush, Z. Molvi, P. Das, H. Molina, C. A. Klebanoff, T. Walz
This study presents cryo-EM structures of the human TCR-CD3 complex in its resting and ligand-bound states, revealing conformational changes and the importance of native lipid environments.
bioRxiv · Aug 22, 2023Biochemistry