M. W. Bush

The resting and ligand-bound states of the membrane-embedded human T-cell receptor-CD3 complex

This study presents cryo-EM structures of the human TCR-CD3 complex in its resting and ligand-bound states, revealing conformational changes and the importance of native lipid environments.

Shelterin is a Dimeric Complex with Extensive Structural Heterogeneity

This study characterizes the structural architecture and conformational variability of the human shelterin complex using multiple biophysical methods.