H. Molina

The lipid droplet protein DHRS3 is a regulator of melanoma cell state

The paper identifies DHRS3 as a lipid droplet protein that regulates melanoma cell state by modulating retinoid signaling.

Fast and accurate disulfide bridge detection

This paper presents a fast and accurate method for detecting disulfide bridges in proteins using mass spectrometry with optimized sample preparation and data analysis.

The Origin and Evolution of Sex Peptide and Sex Peptide Receptor Interactions

This study investigates the evolutionary origin of sex peptide (SP) and sex peptide receptor (SPR) interactions using ancestral sequence reconstruction, AlphaFold2, and molecular dynamics simulations.

Structural and functional insights into the enzymatic plasticity of the SARS-CoV-2 NiRAN Domain

This study determines cryo-EM structures of SARS-CoV-2 NiRAN domain catalytic intermediates, revealing structural mechanisms for NMPylation and deRNAylation/capping, and explaining substrate preference for capping.

The resting and ligand-bound states of the membrane-embedded human T-cell receptor-CD3 complex

This study presents cryo-EM structures of the human TCR-CD3 complex in its resting and ligand-bound states, revealing conformational changes and the importance of native lipid environments.

Magnetogenetic cell activation using endogenous ferritin

This paper develops a magnetogenetic method using anti-ferritin nanobodies and a benchtop electromagnet to activate cells in vivo, improving glucose tolerance in mice.

A pro-metastatic tRNA fragment drives Nucleolin oligomerization and stabilization of bound metabolic mRNAs

The paper identifies a tRNA fragment that promotes Nucleolin oligomerization and stabilizes metabolic mRNAs, enhancing breast cancer metastasis.

Adaptive stimulation of macropinocytosis overcomes aspartate limitation in cancer cells under hypoxia

The paper identifies GOT2-catalyzed mitochondrial aspartate synthesis as essential for pancreatic tumor cell proliferation under hypoxia, but this dependency is bypassed by hypoxia-induced macropinocytosis.

A histone-like motif in yellow fever virus contributes to viral replication

This study identifies a histone-like motif in the yellow fever virus capsid protein that mimics histone H4 and interferes with BRD4-mediated gene regulation, impacting viral replication.

PI31 is an adaptor protein for proteasome transport in axons and required for synaptic development and function

This study identifies PI31 as an adaptor protein linking proteasomes to dynein motors in axons, showing its role in synaptic development and function through regulated transport.