Structural and molecular dynamics of Mycobacterium tuberculosis malic enzyme, a potential anti-TB drug target
K. H. Burley, B. J. Cuthbert, P. Basu, J. Newcombe, E. M. Irimpan, R. Quechol, I. P. Foik, D. L. Mobley, D. J. Beste, C. W. Goulding
This study presents the X-ray structure of Mtb malic enzyme and uses MD simulations to reveal its dynamic behavior, informing potential inhibitor design.
bioRxiv · Jul 7, 2020Biochemistry