Author

D. J. Beste

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 1 Microbiology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Organism:bacteria (other)· 1 Research Focus:host-pathogen & immune response· 1 Organism:mouse· 1 Research Focus:protein structure prediction· 1 Assay:proteomics· 1 Approach:statistical model· 1 Assay:structural biology· 1

Frequent Co-Authors

A. Palande· 1 shared A. Veeram· 1 shared B. J. Cuthbert· 1 shared C. W. Goulding· 1 shared D. L. Mobley· 1 shared E. M. Irimpan· 1 shared G. Larrouy-Maumus· 1 shared I. P. Foik· 1 shared

Activity by Year

2020-2023 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 24 mutual co-author links

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1 shared paperMicrobiology

A. Palande

Mutual co-authors in cluster

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2 papers

Recent·Most cited

ATP burst is the dominant driver of antibiotic lethality in Mycobacterium smegmatis

T. Lodhiya, A. Palande, A. Veeram, G. Larrouy-Maumus, D. J. Beste, R. Mukherjee

The paper investigates how aminoglycoside and fluoroquinolone antibiotics induce cell death in M. smegmatis by increasing TCA cycle flux, ATP production, and ROS, with ATP levels being the primary driver of lethality.

bioRxiv · Sep 11, 2023 · PreprintMicrobiology

Structural and molecular dynamics of Mycobacterium tuberculosis malic enzyme, a potential anti-TB drug target

K. H. Burley, B. J. Cuthbert, P. Basu, J. Newcombe, E. M. Irimpan, R. Quechol, I. P. Foik, D. L. Mobley, D. J. Beste, C. W. Goulding

This study presents the X-ray structure of Mtb malic enzyme and uses MD simulations to reveal its dynamic behavior, informing potential inhibitor design.

bioRxiv · Jul 7, 2020Biochemistry