Author

J. Newcombe

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

Click to filter author papers

Biochemistry· 1 Microbiology· 1

Signature Assays, Organisms & Methods

Click to filter · or open tag

Approach:experimental assay· 2 Organism:bacteria (other)· 1 Research Focus:host-pathogen & immune response· 1 Organism:human· 1 Research Focus:protein structure prediction· 1 Assay:proteomics· 1 Approach:statistical model· 1 Assay:structural biology· 1

Frequent Co-Authors

B. J. Cuthbert· 1 shared B. S. Hall· 1 shared C. W. Goulding· 1 shared D. J. Beste· 1 shared D. L. Mobley· 1 shared E. M. Irimpan· 1 shared F. J. Salguero· 1 shared I. P. Foik· 1 shared

Activity by Year

2020-2023 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 24 mutual co-author links

Click any collaborator node to inspect or filter shared papers

Focal author (center)Selected co-authorORCID co-authorUnlinked name

Curved chords = mutual co-authorship

1 shared paperBiochemistry

B. J. Cuthbert

Mutual co-authors in cluster

Author profile →

2 papers

Recent·Most cited

Mycolactone causes destructive Sec61-dependent loss of the endothelial glycocalyx and vessel basement membrane: a new indirect mechanism driving tissue necrosis in Mycobacterium ulcerans infection

L. T.-H. Hsieh, B. S. Hall, J. Newcombe, T. A. Mendum, S. Santana-Varela, Y. Umrania, M. J. Deery, W. Q. Shi, J. Diaz Delgado, F. J. Salguero, R. E. Simmonds

This study shows mycolactone causes endothelial glycocalyx and basement membrane loss via Sec61-dependent mechanisms, leading to vascular dysfunction and tissue necrosis in Buruli ulcer.

bioRxiv · Feb 21, 2023Microbiology

Structural and molecular dynamics of Mycobacterium tuberculosis malic enzyme, a potential anti-TB drug target

K. H. Burley, B. J. Cuthbert, P. Basu, J. Newcombe, E. M. Irimpan, R. Quechol, I. P. Foik, D. L. Mobley, D. J. Beste, C. W. Goulding

This study presents the X-ray structure of Mtb malic enzyme and uses MD simulations to reveal its dynamic behavior, informing potential inhibitor design.

bioRxiv · Jul 7, 2020Biochemistry