α-Helix stabilization by co-operative side chain charge-reinforced interactions to phosphoserine in a basic kinase-substrate motif
M. Batchelor, R. S. Dawber, A. J. Wilson, R. Bayliss
The paper shows phosphorylation stabilizes an α-helix in a kinase-substrate motif through charge-reinforced side chain interactions, with phosphorylation of Ser promoting helix formation and Thr inducing an opposing response.
bioRxiv · Nov 27, 2021Biochemistry