R. Bayliss

Regulation of Human PINK1 ubiquitin kinase by Serine167, Serine228 and Cysteine412 phosphorylation

This study identifies phosphorylation sites in hPINK1 that regulate its activation and ubiquitin interaction, revealing a novel inhibitory mechanism involving pCys412.

Efficient Viral Capture and Inactivation from Bioaerosols Using Electrostatic Precipitation.

This study evaluates electrostatic precipitation as a method to capture and inactivate viral particles in bioaerosols during laparoscopic surgery, showing effectiveness against both enveloped and non-enveloped viruses.

Exploring the conformational landscape and stability of Aurora A using ion-mobility mass spectrometry and molecular modelling

This study uses ion-mobility mass spectrometry and molecular modeling to analyze conformational changes in Aurora A kinase induced by TPX2 activation and inhibitor binding.

α-Helix stabilization by co-operative side chain charge-reinforced interactions to phosphoserine in a basic kinase-substrate motif

The paper shows phosphorylation stabilizes an α-helix in a kinase-substrate motif through charge-reinforced side chain interactions, with phosphorylation of Ser promoting helix formation and Thr inducing an opposing response.

Mapping of a N-terminal α-helix domain required for human PINK1 stabilisation, Serine228 autophosphorylation and activation in cells

This study identifies an N-terminal α-helix domain in PINK1 critical for its stabilization, autophosphorylation, and activation, linking mutations in this region to Parkinson's disease.

A point mutation in the kinase domain of CRK10 leads to xylem vessel collapse and activates defence responses

A point mutation in CRK10's kinase domain causes xylem vessel collapse and activates defense responses in Arabidopsis.

Defining endogenous TACC3-chTOG-clathrin-GTSE1 interactions at the mitotic spindle using induced relocalization

This paper identifies core and ancillary members of the TACC3-chTOG-clathrin-GTSE1 complex and shows PIK3C2A is not part of the complex, suggesting strategies to disrupt mitotic spindle stability.

Phase-separation of EML4-ALK variant 3 is dependent upon an active ALK conformation

This study shows that EML4-ALK V3 forms liquid droplets dependent on ALK's active conformation, and different TKIs affect droplet formation and protein localization differently.

EML4-ALK V3 drives cell migration through NEK9 and NEK7 kinases in non-small-cell lung cancer

The paper shows EML4-ALK V3 promotes cell migration via NEK9 and NEK7 kinases, leading to worse outcomes in lung cancer.

Covalent Aurora A regulation by the metabolic integrator coenzyme A

This study identifies a novel covalent inhibition mechanism of Aurora A kinase by coenzyme A, showing its regulation under oxidative stress and impact on meiotic spindle formation.

Mitotic phosphorylation by Nek6 and Nek7 reduces microtubule affinity of EML4 to alter spindle dynamics and promote chromosome congression