A. J. Wilson

Absence of CD47 in the tumor microenvironment modulates tumor metabolism and immunosuppressive signatures limiting breast cancer progression.

This paper shows that CD47 absence in tumors reduces tumor burden and enhances immune response by altering metabolism and immunosuppressive signatures in breast cancer.

Profiling sorghum-microbe interactions with a specialized photoaffinity probe identifies key sorgoleone binders in Acinetobacter pittii

This paper uses a sorgoleone-based photoaffinity probe to identify proteins in Acinetobacter pittii that bind sorgoleone, revealing potential pathways for microbial interaction with this plant metabolite.

Genetic integration of behavioural and endocrine components of the stress response

This study shows that acute stress response traits in Trinidadian guppies are heritable and genetically integrated, suggesting potential for artificial selection to improve health and welfare in captive populations.

Amino acid availability determines plant immune homeostasis in the rhizosphere microbiome

This study shows that bacterial amino acid biosynthesis prevents rhizosphere alkalization and immune activation in Arabidopsis by reducing glutamate precursors.

Understanding the interaction of 14-3-3 proteins with hDMX and hDM2: a structural and biophysical study

The paper investigates the structural and biophysical interactions between 14-3-3 proteins and hDMX/hDM2, identifying key phosphosites that enable high-affinity binding.

Understanding p300-transcription factor interactions using sequence variation and hybridization

The paper investigates HIF-1 sequence variation tolerance using biochemical assays, showing that sequence changes are tolerated through disordered binding interactions.

α-Helix stabilization by co-operative side chain charge-reinforced interactions to phosphoserine in a basic kinase-substrate motif

The paper shows phosphorylation stabilizes an α-helix in a kinase-substrate motif through charge-reinforced side chain interactions, with phosphorylation of Ser promoting helix formation and Thr inducing an opposing response.

Mothers front-load their investment to the egg stage when helped in a wild cooperative bird

The paper shows that mothers in cooperative bird species increase pre-natal investment when helped by female helpers, by laying larger eggs, while reducing post-natal investment.

A multivariate view of cognitive performance reveals positive correlation in the Trinidadian Guppy (Poecilia reticulata)

The paper examines cognitive performance variation in Trinidadian guppies using a multivariate approach and finds strong positive correlations among cognitive tasks and personality traits.

The genetic and social contributions to sex differences in lifespan in Drosophila serrata

This study tests the unguarded X hypothesis for sex differences in lifespan in Drosophila serrata by examining genotype, sex, social environment, and their interactions.

Using genomic prediction to detect microevolutionary change of a quantitative trait

This study uses genomic prediction to detect microevolutionary changes in adult body weight of Soay sheep over 35 years, finding an increase in the genetic component despite a decrease in average body weight.

Loss of a plant receptor kinase recruits beneficial rhizosphere-associated Pseudomonas

This study identifies FERONIA kinase's role in regulating NADPH oxidase to control rhizosphere Pseudomonas levels in Arabidopsis.

Natural selection reverses the exaggeration of a male sexually selected trait, which increases female fitness.

The paper uses experimental evolution to show that male-specific predation reduces exaggerated male traits in beetles, indirectly increasing female fitness through genetic correlations.

Quantifying and modelling the acquisition and retention of lumpy skin disease virus by haematophagus insects reveals clinically but not subclinically-affected cattle are promoters of viral transmission and key targets for control of disease outbreaks.

This study quantifies LSDV acquisition and retention by vector insects and models transmission, finding clinical cattle are key promoters of viral spread and highlighting the need for targeted control strategies.

Individual differences in spatial learning are correlated across cognitive tasks but not associated with stress response behaviour in the Trinidadian guppy

The paper tests if spatial learning ability in Trinidadian guppies correlates with stress response behaviour, finding no association but repeatable individual differences in learning.

Inter-domain dynamics in the chaperone SurA and multi-site binding to its unfolded outer membrane protein clients

This study investigates the conformational dynamics of SurA and its interaction with unfolded OMP clients using multiple biophysical techniques.

Selective Affimers Recognize BCL-2 Family Proteins Through Non-Canonical Structural Motifs

The paper identifies Affimer reagents that selectively bind BCL-2 family proteins through non-canonical structural motifs, showing competitive inhibition and conformational changes.

Social effects of territorial neighbours on the timing of spring breeding in North American red squirrels

The paper estimates indirect phenotypic and genetic effects of territorial neighbors on spring breeding timing in red squirrels, finding stronger social effects at high population densities.

Habituation and individual variation in the endocrine stress response in the Trinidadian guppy (Poecilia reticulata)

This study shows Trinidadian guppies habituate quickly to repeated stress exposure and exhibit consistent individual differences in their endocrine stress response.