Mechanistic Insights into Impaired cGAS Activation in Staphylococcus aureus Biofilm Environments Reveal That STING Activation via 2'3'-cGAMP Restores Macrophage Immune Responses
Elisabeth Seebach, Carlos E Perez Cevallos, R. Schumacher, Katharina F. Kubatzky
This study identifies mechanisms by which Staphylococcus aureus biofilms impair cGAS-STING signaling in macrophages, showing that direct STING activation with 2'3'-cGAMP restores immune responses.
bioRxiv · Apr 1, 2026 · PreprintImmunology