Author

Elisabeth Seebach

Heidelberg University

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Immunology· 2 Biochemistry· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Research Focus:host-pathogen & immune response· 2 Approach:biophysical modeling· 1 Research Focus:cell signaling & trafficking· 1 Research Focus:development & morphogenesis· 1 Research Focus:drug response / drug discovery· 1 Organism:human· 1 Organism:mouse· 1

Frequent Co-Authors

Katharina F. KubatzkyiD· 2 shared Axel MogkiD· 1 shared Bernd BukauiD· 1 shared Britta Jehle· 1 shared Carlos E Perez Cevallos· 1 shared Dirk FlemmingiD· 1 shared Hannah F Simonis· 1 shared Irmgard SinningiD· 1 shared

Activity by Year

2026-2026 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 19 mutual co-author links

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2 shared papersImmunology

Katharina F. KubatzkyORCID

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

Small-molecule activators of the Staphylococcus aureus ClpC/ClpP AAA+ protease

Timo Jenne, Vsevolod Viliuga, Ulrike Uhrig, Britta Jehle, Merlin Schwan, Jürgen Kopp, Dirk Flemming, Elisabeth Seebach, Irmgard Sinning, Bernd Bukau, Axel Mogk

The paper identifies small-molecule activators of the Staphylococcus aureus ClpC/ClpP protease through high-throughput screening and characterizes their binding sites.

iScience · Sep 22, 2026Peer-reviewedBiochemistry

cGAS-STING induced IFN-β acts as a dual regulator of osteoclastogenesis via direct and osteoblast-mediated mechanisms

Hannah F Simonis, Sanya Middha, Loris Graf, Ramin Naibi, Vivian Polenz, Katharina F. Kubatzky, Elisabeth Seebach

This study shows cGAS-STING-IFN-β signaling regulates osteoclastogenesis both directly in macrophages and indirectly through osteoblasts by altering the OPG-RANKL axis.

bioRxiv · May 13, 2026 · PreprintImmunology

Mechanistic Insights into Impaired cGAS Activation in Staphylococcus aureus Biofilm Environments Reveal That STING Activation via 2'3'-cGAMP Restores Macrophage Immune Responses

Elisabeth Seebach, Carlos E Perez Cevallos, R. Schumacher, Katharina F. Kubatzky

This study identifies mechanisms by which Staphylococcus aureus biofilms impair cGAS-STING signaling in macrophages, showing that direct STING activation with 2'3'-cGAMP restores immune responses.

bioRxiv · Apr 1, 2026 · PreprintImmunology