Inhibition of Bruton's tyrosine kinase activity attenuates trauma-induced multiple organ dysfunction in rats
N. M. Patel, F. R. Oliveira, H. Pillmann Ramos, E. Aimaretti, G. Ferreira Alves, S. M. Coldewey, M. Collino, R. Sordi, C. Thiemermann
This study shows that BTK inhibitors reduce trauma-induced multiple organ dysfunction in rats by inhibiting BTK, NF-κB, and NLRP3 activation.
bioRxiv · Sep 23, 2021Pharmacology & Toxicology