FGFR inhibitor mediated dismissal of SWI/SNF complexes from YAP-dependent enhancers induces adaptive therapeutic resistance
Y. Li, X. Qiu, X. Wang, H. Liu, R. Geck, A. K. Tewari, T. Xiao, A. Font-Tello, K. Lim, J. L. Kristen, M. Morrow, R. Vadhi, P.-L. Kao, A. Jaber, S. Yerrum, , M. Brown
The paper shows that FGFR inhibitors cause SWI/SNF complex dismissal from YAP-dependent enhancers, leading to adaptive resistance in TNBC through epigenetic and metabolic changes.
bioRxiv · Mar 2, 2021Cancer Biology