Immune Response of Transplanted Kidney Tissues Assembled from Organoid Building Blocks
T. J. Borges, Y. Ganchiku, J. O. Aceves, R. van Gaal, S. G. M. Uzel, J. E. Rubins, K. Kobayashi, K. Hiratsuka, M. Tekguc, I. A. Rosales, G. T. Ribas, K. Lima, R. B. Gassen, R. Morizane, J. A. Lewis, L. V. Riella
This study transplants engineered kidney tissues made from organoid building blocks into mice with human immune cells to assess immune response and tissue integration, finding immune infiltration causes tissue injury similar to transplant rejection.
bioRxiv · Aug 26, 2023 · PreprintBioengineering