Novel Role of UHRF1 in DNA methylation-mediated repression of latent HIV-1
R. Verdikt, S. Bouchat, A. O. Pasternak, L. Nestola, G. Darcis, V. Avettand-Fenoel, C. Vanhulle, A. Ait-Ammar, M. Bendoumou, E. Plant, V. Le Douce, N. Delacourt, A. Cicilionyte, C. Necsoi, F. Corazza, , C. Van Lint
This study identifies UHRF1 as a novel mediator of HIV-1 latency through DNA methylation and shows its inhibition reactivates latent HIV-1 in patient cells.
bioRxiv · Jun 15, 2021Microbiology