A. Saez-Cirion

Antiviral capacity of the early CD8 T-cell response is predictive of natural control of SIV infection

This study uses mathematical modeling of SIV-infected macaques to show that early CD8 T-cell suppressive capacity predicts natural control of infection.

HIV-1 hijacks the cell extracellular matrix to spread collectively and efficiently between T lymphocytes

This study shows HIV-1 spreads between T lymphocytes via extracellular matrix (ECM)-clustered viral particles, enhancing transmission efficiency and resistance to antiretroviral treatment and antibodies.

Novel Role of UHRF1 in DNA methylation-mediated repression of latent HIV-1

This study identifies UHRF1 as a novel mediator of HIV-1 latency through DNA methylation and shows its inhibition reactivates latent HIV-1 in patient cells.

Anti-apoptotic clone 11 derived peptides induce in vitro death of CD4+ T cells susceptible to HIV-1 infection

The paper shows that AAC-11-derived peptides induce death of HIV-1 susceptible CD4+ T cells by targeting metabolically active cells.

Modeling SIV kinetics supports that cytotoxic response drives natural control and unravels heterogeneous populations of infected cells

Modeling SIV dynamics in natural controller macaques shows viral control is driven by early cytotoxic T-cell response and reveals distinct infected cell compartments with different turnover rates.

Optimal maturation of the SIV-specific CD8+ T-cell response after primary infection is associated with natural control of SIV. ANRS SIC study

This study shows that optimal maturation of SIV-specific CD8+ T-cells correlates with natural control of SIV infection in macaques, with controllers developing more potent antiviral responses over time.