Cancer BiologybioRxivPreprint
TP63, SOX2 and KLF5 Establish Core Regulatory Circuitry and Construct Cancer Specific Epigenome in Esophageal Squamous Cell Carcinoma
Y. Jiang, Y. Jiang, C.-Q. Li…·H. P. Koeffler
This study identifies TP63, SOX2, and KLF5 as core regulatory circuitry transcription factors in ESCC that drive epigenetic modifications and tumor growth through super-enhancer interactions.