Author

H. P. Koeffler

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 5

Signature Assays, Organisms & Methods

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Organism:human· 5 Assay:ChIP-seq· 4 Approach:experimental assay· 4 Research Focus:gene regulatory network inference· 4 Research Focus:differential expression· 3 Approach:statistical model· 3 Assay:ATAC-seq· 2 Research Focus:cell type annotation· 2

Frequent Co-Authors

D.-C. Lin· 4 shared B. P. Berman· 2 shared Q. Yang· 2 shared S. Gery· 2 shared T. C. Silva· 2 shared Y. Zheng· 2 shared A. A. Lane· 1 shared A. Louissaint· 1 shared

Activity by Year

2019-2020 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 20 mutual co-author links

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4 shared papersCancer Biology

D.-C. Lin

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5 papers

Recent·Most cited

Sex-biased ZRSR2 mutations in myeloid malignancies impair plasmacytoid dendritic cell activation and apoptosis

K. Togami, S. S. Chung, V. Madan, L. Cabal-Hierro, J. Taylor, S. S. Kim, G. K. Griffin, M. Ghandi, J. Li, Y. Y. Li, F. Angelot-Delettre, S. Biichle, M. Seiler, S. Buonamici, S. B. Lovitch, , A. A. Lane

The paper identifies sex-biased ZRSR2 mutations in BPDCN that impair pDC activation and apoptosis, linking X chromosome mutations to male-predominant leukemia.

bioRxiv · Oct 29, 2020Cancer Biology

A pan-cancer analysis of CpG Island gene regulation reveals extensive plasticity within Polycomb targets

Y. Zheng, G. Huang, T. C. Silva, Q. Yang, H. P. Koeffler, B. P. Berman, D.-C. Lin

The paper analyzes CpG Island gene regulation across cancers, finding that PRC2+-CGI genes show both upregulation and hypermethylation in different cancer types, indicating regulatory plasticity.

bioRxiv · Jun 4, 2020Cancer Biology

EWS-FLI1 regulates and cooperates with core regulatory circuitry in Ewing sarcoma

X. Shi, Y. Zheng, L. Jiang, B. Zhou, W. Yang, L. Li, L. Ding, M. Huang, S. Gery, D.-C. Lin, H. P. Koeffler

This study identifies and validates a core regulatory circuitry trio in Ewing sarcoma, showing how EWS-FLI1 and CRC factors regulate transcription and epigenome, with implications for therapy.

bioRxiv · Jan 15, 2020Cancer Biology

TP63, SOX2 and KLF5 Establish Core Regulatory Circuitry and Construct Cancer Specific Epigenome in Esophageal Squamous Cell Carcinoma

Y. Jiang, Y. Jiang, C.-Q. Li, Z. Ying, P. Dakle, J.-W. Deng, R. Y.-T. Lin, H. Kaur, L. Han, J.-J. Xie, A. Mayakonda, M. Hazawa, L. Xu, Y. Li, L. Aswad, , H. P. Koeffler

This study identifies TP63, SOX2, and KLF5 as core regulatory circuitry transcription factors in ESCC that drive epigenetic modifications and tumor growth through super-enhancer interactions.

bioRxiv · Nov 6, 2019 · PreprintCancer Biology

Lineage-Specific Epigenomic and Genomic Activation of the Oncogene HNF4A Promotes Gastrointestinal Adenocarcinomas

J. Pan, T. C. Silva, N. Gull, Q. Yang, J. Plummer, S. Chen, K. Daigo, T. Hamakubo, S. Gery, L.-W. Ding, Y.-Y. Jiang, S.-Y. Hu, L.-Y. Xu, E.-M. Li, Y. Ding, , D.-C. Lin

The paper identifies lineage-specific activation of HNF4A in gastrointestinal adenocarcinomas through epigenomic and genomic analysis, revealing its role in promoting cancer proliferation.

bioRxiv · Oct 21, 2019Cancer Biology