Molecular BiologybioRxiv
The fail-safe mechanism of post-transcriptional silencing of unspliced HAC1 mRNA
Rachael Di Santo, Soufiane Aboulhouda, David E Weinberg
This study identifies a fail-safe mechanism that prevents Hac1 protein accumulation from unspliced HAC1 mRNA in yeast when the UPR is inactive, involving inhibited translation initiation and accelerated degradation.
DOI 10.7554/elife.20069