ADAR1 haploinsufficiency and sustained viral RdRp dsRNA synthesis synergize to dysregulate RNA editing and cause multi-system interferonopathy
Caitlin M. Miller, James H. Morrison, Laura Bankers, Rachael J. Dran, Julia Kendrick, Emma Briggs, Virginia L. Ferguson, Eric M. Poeschla
The paper shows that ADAR1 haploinsufficiency combined with viral RdRp dsRNA synthesis causes dysregulated RNA editing and multi-system interferonopathy.
bioRxiv · Jan 21, 2025 · PreprintImmunology