The bacterial chaperone CsgC inhibits functional amyloid CsgA formation by promoting the intrinsically disordered pre-nuclear state
Anthony Balistreri, Divya Kolli, Sanduni Wasana Jayaweera, Daniel Lundahl, Yilin Han, Lily Kalcec, Emily Goetzler, Rachel Alessio, Brandon T. Ruotolo, Anders Olofsson, Matthew R. Chapman
This study shows CsgC inhibits CsgA amyloid formation by interacting with pre-nuclear and fibrillar states, delaying nucleation and slowing fiber growth.
Journal of Biological Chemistry · May 8, 2025Peer-reviewedBiochemistry