Brandon T. Ruotolo

This study uses cryo-EM to capture intermediate states of maltooligosaccharide transport by the SusCD complex in Bacteroides, revealing its heterodimeric structure and binding mechanisms.

This study shows CsgC inhibits CsgA amyloid formation by interacting with pre-nuclear and fibrillar states, delaying nucleation and slowing fiber growth.

This study characterizes the RNA-binding properties of a disordered protein, SERF, and shows that binding to RNA causes modest global compaction without inducing structural changes in either molecule.

This study presents the crystal structures of Sas6 and RbCBM74 bound to maltodecaose, showing their binding specificity for single and double helical α-glucan structures in starch.