Xylazine exacerbates fentanyl-induced respiratory depression and prevents rescue by naloxone in mice
Joshua M. Watkins, Rachel Hahn, Michael Dempsey, Andrea G. Hohmann
This study shows that xylazine worsens fentanyl-induced respiratory depression and prevents naloxone reversal, but can be counteracted by combining naloxone with atipamezole in mice.
Psychopharmacology · Mar 23, 2026Peer-reviewedNeuroscience