Chimeric Antigen Receptors Transmit Piconewton Forces that are Coupled with T Cell Function
Rachel M. Fitzgerald, Areeba A. Hashmi, Anna M. Davis, Alexander K. Foote, Gianna M. Branella, Jhordan Rogers, Emily C Sullivan, Mehdi Rahman, Sunil S. Raikar, Khalid S. Salaita
This study measures piconewton forces transmitted by CAR T cells to their targets and links force magnitude to T cell function and exhaustion.
bioRxiv · Oct 23, 2025 · PreprintBiophysics