Khalid S. Salaita

This paper develops an RNA-free DNA motor powered by Exonuclease III, demonstrating autonomous rolling motion and biosensing capabilities through aptamer-functionalized components.

The paper shows that antigen clustering on follicular dendritic cells enhances B-cell receptor activation through geometric control of tyrosine phosphatase exclusion.

This study measures piconewton forces transmitted by CAR T cells to their targets and links force magnitude to T cell function and exhaustion.

This paper develops a DNA tension sensor to measure integrin force loading rates in live cells, revealing exponential decay in bond lifetime and localized high-force events at cell-substrate junctions.

This study shows that the adipocyte niche impairs T-cell function by modulating cytoskeletal dynamics and reducing TCR-antigen forces in both mice and human T-cells.