The Pathological Role and Therapeutic potential of ALDH2 in acrolein detoxification Following Spinal Cord Injury in Mice
Riyi Shi, Siyuan Sun, Seth Herr, Anna Alford, Rachel Stingel, Zaiyang Zhang, Timothy Dong
This study investigates ALDH2's role in SCI by genetically impairing and pharmacologically enhancing its activity, showing Alda-1 reduces acrolein levels and improves recovery, especially in ALDH2*2 mice.
bioRxiv · Jun 8, 2025 · PreprintNeuroscience