Ser500 phosphorylation acts as a conformational switch to prime eEF-2K for activation
Amanda L. Bohanon, Luke Samuel Browning, Andrea Piserchio, Kimberly J. Long, Sharon Jacob, Rae M. Sammons, Clint D.J. Tavares, Eun Jeong Cho, Ranajeet Ghose, Kevin N. Dalby
This study shows that S500 phosphorylation primes eEF-2K for activation by enhancing its intrinsic activity and facilitating CaM-dependent activation.
Journal of Biological Chemistry · Dec 22, 2025Peer-reviewedBiochemistry