NAMPT activation uncovers a senescence-specific vulnerability and promotes healthy aging in combination with NAM
Michael Alcaraz, Raghuveer Ramachandra, Rouven Arnold, Marcos G. Teneche, Adarsh Rajesh, Laurence Haddadin, Mey Taing, Xue Lei, Armin Gandhi, Theophilos Tzaridis, Karl N. Miller, Jessica Proulx, Amirhossein Nayeri Rad, Andrew Davis, Angela Liou, , Peter D. Adams
This paper identifies a strategy combining NAMPT activation and NAM supplementation to target NAD+ dysregulation and senescent cells, promoting healthy aging in mice.
bioRxiv · Aug 7, 2026 · PreprintMolecular Biology