Author

Michael Alcaraz

Sanford Burnham Prebys Medical Discovery Institute

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cell Biology· 1 Genomics· 1 Molecular Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Organism:mouse· 3 Assay:bulk RNA-seq· 1 Research Focus:cancer & tumor microenvironment· 1 Research Focus:cell type annotation· 1 Research Focus:development & morphogenesis· 1 Research Focus:differential expression· 1 Assay:DNA methylation· 1

Frequent Co-Authors

Adarsh RajeshiD· 3 shared Andrew Davis· 3 shared Angela LiouiD· 3 shared Armin GandhiiD· 3 shared Hiroshi TanakaiD· 3 shared Karl N. MilleriD· 3 shared Laurence HaddadiniD· 3 shared Marcos G. TenecheiD· 3 shared

Activity by Year

2026-2026 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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3 shared papersCell Biology

Adarsh RajeshORCID

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

Targeting CyclinD1-CDK6 to Mitigate Senescence-Driven Inflammation and Age-Associated Functional Decline

Adarsh Rajesh, Aaron P. Havas, Rouven Arnold, Kathryn Lande, Xue Lei, Kelly Yichen Li, Armin Gandhi, Ana Catarina Franco, Seung‐Hwa Woo, Anthony B. Lagnado, Angela Liou, K. Garrett Evensen, Linshan Laux, Maggie Klaers, Jake Kircher, , Peter D. Adams

This study shows that targeting CCND1-CDK6 reduces DNA damage, inflammation, and age-related decline in mice by suppressing SASP and ISG expression.

Nature Aging · Aug 20, 2026Peer-reviewedCell Biology

NAMPT activation uncovers a senescence-specific vulnerability and promotes healthy aging in combination with NAM

Michael Alcaraz, Raghuveer Ramachandra, Rouven Arnold, Marcos G. Teneche, Adarsh Rajesh, Laurence Haddadin, Mey Taing, Xue Lei, Armin Gandhi, Theophilos Tzaridis, Karl N. Miller, Jessica Proulx, Amirhossein Nayeri Rad, Andrew Davis, Angela Liou, , Peter D. Adams

This paper identifies a strategy combining NAMPT activation and NAM supplementation to target NAD+ dysregulation and senescent cells, promoting healthy aging in mice.

bioRxiv · Aug 7, 2026 · PreprintMolecular Biology

HIRA-mediated H3.3 deposition preserves hepatocyte cell identity during liver aging

Rouven Arnold, Marcos G. Teneche, Xue Lei, Armin Gandhi, Christina Huan Shi, Jessica M. Proulx, Adarsh Rajesh, Aaron P. Havas, Shiqi Su, Annanya Sethiya, Shanshan Yin, Hiroshi Tanaka, Zong Ming Chua, Andrew Davis, Laurence Haddadin, , Peter D. Adams

This study shows that HIRA-mediated H3.3 deposition maintains hepatocyte identity during aging, and its loss leads to metabolic dysfunction and fibrosis, which can be partially reversed by tissue regeneration.

bioRxiv · Mar 11, 2026 · PreprintGenomics