Identification and characterization of a small-molecule inhibitor of the Pseudomonas aeruginosa SOS response
Filippo Vascon, Benedetta Fongaro, Vytautas Mickevičius, Antonella Pasquato, Birutė Grybaitė, Vidmantas Petraitis, Rahma Ben Abderrazek, Patrizia Polverino de Laureto, Donatella Tondi, Povilas Kavaliauskas, Laura Cendron
This study identifies and characterizes a small-molecule inhibitor, A12, of the SOS response in Pseudomonas aeruginosa, showing it binds RecA and LexA and forms disulfide bonds, with potential for anti-SOS compound development.
ACS Infectious Diseases · Nov 7, 2025Peer-reviewedBiochemistry