Anle138b manifests potent anti-hyperglycemic activity in type 2 diabetic mice expressing hIAPP
Mohammed M. H. Albariqi, Sanne M.G. Baauw, Sjors J.P.J. Fens, Sabine Versteeg, Sergey Ryazanov, Andrei Leonov, Hanneke L.D.M. Willemen, Nikolas Stathonikos, Raina Marie Seychell, Adam El Saghir, Bram Gerritsen, Lucie Khemtémourian, Neville Vassallo, Armin Giese, Niels Eijkelkamp, , Jo W.M. Höppener
This study shows that anle138b reduces hyperglycemia and improves pancreatic islet function in hIAPP Ob/Ob mice by mitigating hIAPP toxicity.
bioRxiv · Aug 27, 2024 · PreprintPathology