This paper shows that anle138b binds to a cavity in lipidic Aβ fibrils and reduces fibril formation by 75%, suggesting a potential therapeutic mechanism for Alzheimer's disease.

bioRxiv · May 30, 2025 · PreprintBiochemistry

Structural insight into binding of novel PET tracer MODAG-005 to lipidic ????-Synuclein fibrils

Myeongkyu Kim, Dirk Matthes, Benedikt Frieg, Andrei Leonov, Sergey Ryazanov, Daniel Bleher, Ann-Kathrin Grotegerd, Christian Dienemann, Armin Giese, G.F. Schroeder, Stefan Becker, Kristina Herfert, Bert L. de Groot, Loren B. Andreas, Christian Griesinger

This study identifies two binding sites of the PET tracer MODAG-005 on lipidic α-synuclein fibrils, with the cavity site being more stable and selectively occupied under certain conditions.

bioRxiv · Apr 21, 2025 · PreprintBiochemistry

Anle138b manifests potent anti-hyperglycemic activity in type 2 diabetic mice expressing hIAPP

Mohammed M. H. Albariqi, Sanne M.G. Baauw, Sjors J.P.J. Fens, Sabine Versteeg, Sergey Ryazanov, Andrei Leonov, Hanneke L.D.M. Willemen, Nikolas Stathonikos, Raina Marie Seychell, Adam El Saghir, Bram Gerritsen, Lucie Khemtémourian, Neville Vassallo, Armin Giese, Niels Eijkelkamp, , Jo W.M. Höppener

This study shows that anle138b reduces hyperglycemia and improves pancreatic islet function in hIAPP Ob/Ob mice by mitigating hIAPP toxicity.

bioRxiv · Aug 27, 2024 · PreprintPathology

Toxicity of extracellular alpha-synuclein is independent of intracellular alpha-synuclein

Yanina Dening, Theresa Straßl, Viktoria Ruf, Petra Dirscherl, Alexandra Chovsepian, Aliçia Stiévenard, Amit Khairnar, Felix Schmidt, Florian Giesert, Jochen Wolfgang Herms, Johannes Levin, Marianne Dieterich, Peter Falkai, Daniela M. Vogt Weisenhorn, Wolfgang Wurst, , Francisco J. Pan-Montojo

This study shows that extracellular alpha-synuclein toxicity in Parkinson's disease is independent of intracellular alpha-synuclein and linked to mitochondrial dysfunction.

Scientific Reports · Dec 19, 2022Peer-reviewedNeuroscience

A meta-analysis of epigenome-wide association studies in Alzheimer's disease highlights novel differentially methylated loci across cortex

Rebecca G. Smith, Ehsan Pishva, Gemma L. Shireby, Adam R. Smith, Janou A. Y. Roubroeks, Eilis J. Hannon, Greg Wheildon, Diego Mastroeni, Gilles Gasparoni, Markus J. Riemenschneider, Armin Giese, Andrew J. Sharp, Leonard C. Schalkwyk, Vahram H. Haroutunian, Wolfgang Viechtbauer, , Katie Lunnon

This study performs a meta-analysis of DNA methylation data from Alzheimer's disease patients to identify differentially methylated loci across brain regions and cortex.

Nature Communications · Jun 10, 2021Peer-reviewedGenomics

Depopulation of α-synuclein aggregates is associated with rescue of dopamine neuron dysfunction and death in a new Parkinson disease model

Michał Węgrzynowicz, Dana Bar-On, Laura Calò, Oleg V. Anichtchik, Mariangela Iovino, Jing Xia, Sergey Ryazanov, Andrei Leonov, Armin Giese, Jeffrey W. Dalley, Christian Griesinger, Uri Ashery, Maria Grazia Spillantini

This study develops a new Parkinson's disease mouse model showing that reducing α-synuclein aggregates rescues dopamine neuron dysfunction and death.

Acta Neuropathologica · May 31, 2019Peer-reviewedNeuroscience