Inflammatory endothelial cells promote infiltration of antigen-licensed cytotoxic T cells in malignant gliomas after irradiation
Clara Tejido, Niklas Graßl, Nirmeen Elmadany, Jakob Rosenbauer, Zaira Seferbekova, Khwab Sanghvi, Dennis Alexander Agardy, Ralph Sinn, Theresa Bunse, Anna Mathioudaki, Kristine Jähne, Jana K. Sonner, Michael O. Breckwoldt, Abigail Kora Suwala, Moritz Gerstung, , Katharina Sahm
The paper shows that irradiation reprograms tumor endothelium to enhance T cell infiltration and effector function in gliomas, improving immunotherapy outcomes.
bioRxiv · Jul 13, 2026 · PreprintImmunology