Anna Mathioudaki

This study identifies a specific leukemic stem cell (LSC) subtype that drives niche remodeling in AML by altering fibroblast states and suppressing osteolineage differentiation.

The paper shows that irradiation reprograms tumor endothelium to enhance T cell infiltration and effector function in gliomas, improving immunotherapy outcomes.

This study uses single-cell transplantation and mathematical modeling to show that lineage biases in hematopoiesis arise from extrinsic feedback and clonal competition, not intrinsic HSC properties.

This study identifies treatment-resistant stem-like T-ALL cells that expand during relapse using single-cell RNA sequencing of pediatric T-ALL patient samples.

Segger improves cell segmentation in spatial transcriptomics by using a graph neural network, achieving high sensitivity and speed with minimal manual intervention.

This study uses multiomics analysis of BMSCs to show age-related changes in enhancer activity and gene regulation contribute to immune traits and tissue-specific disorders.