Michael O. Breckwoldt

Tissue resident CD4+ memory T-cells mark response to immune checkpoint inhibition in high-grade glioma

The paper identifies CD4+ tissue-resident memory T-cells as markers of response to immune checkpoint inhibition in high-grade glioma.

Inflammatory endothelial cells promote infiltration of antigen-licensed cytotoxic T cells in malignant gliomas after irradiation

The paper shows that irradiation reprograms tumor endothelium to enhance T cell infiltration and effector function in gliomas, improving immunotherapy outcomes.

Collective cancer cell calcium activity drives brain metastasis

The paper shows brain metastases form gap-junction-coupled networks with coordinated calcium activity that drives proliferation and is inhibited by gap junction blockers.

Voxel-accurate MRI-microscopy correlation enables AI-powered prediction of brain disease states

BRIDGE correlates MRI with cellular data to predict brain disease states using deep learning and high-resolution microscopy.

Characterizing and targeting glioblastoma neuron-tumor networks with retrograde tracing

This study uses retrograde tracing to characterize neuron-tumor networks in glioblastoma and shows that targeting these networks can enhance therapeutic outcomes.

An AI-based segmentation and analysis pipeline for high-field MR monitoring of cerebral organoids

This paper introduces an AI-based pipeline for analyzing cerebral organoids using MRI, achieving high segmentation accuracy and quality classification.

Targeting the TCA cycle can ameliorate widespread axonal energy deficiency in neuroinflammatory lesions

The paper shows that TCA cycle dysfunction contributes to axonal energy deficiency in neuroinflammatory lesions and that restoring TCA enzymes can alleviate this deficit.