CMV Replication Drives IFNγ-Mediated Sensitization of AML Cells to Cytotoxic Killing Through the NKG2C-HLA-E Axis
Wiebke Moskorz, Ron‐Patrick Cadeddu, Markus Uhrberg, Paul Sebastian Jäger, Ralf Grutza, Ramona Grothmann, Mirko Trilling, Sascha Dietrich, Christine Cosmovici, Rainer R. Haas, Joerg Timm
The paper shows CMV replication increases IFNγ, which makes AML cells more vulnerable to NK cell killing via the NKG2C-HLA-E pathway.
bioRxiv · Apr 29, 2026 · PreprintImmunology