Ion-Pair-Free Capillary HILIC-MS for Sensitive Nucleic Acid Analysis and RNA Modification Mapping
Junzhou Wu, Rana Togay, Jingjing Sun, Dwijapriya Dwijapriya, Chi‐Kong Chan, Alex Reading, Liang Cui, Xueming Dong, Peter C. Dedon
This paper develops an ion-pair-free capillary HILIC-MS workflow for RNA modification mapping, enabling sensitive detection of modifications in tRNAs and rRNAs without contaminating the MS system.
bioRxiv · Aug 20, 2026 · PreprintBiochemistry