Jingjing Sun

This paper develops an ion-pair-free capillary HILIC-MS workflow for RNA modification mapping, enabling sensitive detection of modifications in tRNAs and rRNAs without contaminating the MS system.

This study maps tRNA modifications in Streptococcus mutans and S. pneumoniae, revealing shared losses and clade-specific adaptations in modification genes and metabolic strategies.

The paper profiles tRNA modifications in Pseudomonas aeruginosa to uncover regulatory networks and validate gene annotations.

The paper develops a method to map 5'-aldehyde termini in DNA at single-nucleotide resolution, revealing a preference for adenine bases and linking these lesions to genomic features and chromatin accessibility.

The paper shows that tRNA modifications regulate the translational response to mitochondrial stress by altering codon decoding and pathway activity.

This study shows that m6A accumulation correlates more strongly with MAPT pathology than beta-amyloid in an Alzheimer's mouse model.