The Ulcerative Colitis-Associated Gene NXPE1 Catalyzes Glycan Modifications on Colonic Mucin
Ranad Humeidi, Noriko Oshiro-Rapley, Xiebin Gu, Joon Soo An, Ashwin N. Ananthakrishnan, Elizabeth A. Creasey, Mark J. Daly, Stuart L. Schreiber, Daniel B. Graham, Mohammad R. Seyedsayamdost, Ramnik J. Xavier
The paper identifies NXPE1 as an acetyltransferase that modifies mucin glycans in colonic mucus, showing its role in modulating the mucus barrier against commensal microbes in ulcerative colitis.
Journal of the American Chemical Society · Mar 11, 2025Peer-reviewedImmunology