Mohammad R. Seyedsayamdost

This paper introduces an AI system for automated small molecule structure elucidation from NMR spectra, combining generative models with reasoning agents to outperform existing tools.

The paper identifies and characterizes non-canonical CYPs lacking the conserved cysteine ligand, revealing new ligands like serine and selenocysteine in microbial genomes.

This study identifies Todstoff, a novel aversive cue in C. elegans that induces necrotaxis behaviors by signaling through ASH neurons and GPCR pathways.

This study identifies L-xylosone as a human metabolite that mimics the bacterial quorum-sensing autoinducer AI-2, revealing a new host-microbe interaction.

This study investigates how Tryglysin A, a RaS-RiPP produced by Streptococcus, affects ex-vivo oral microbiomes and identifies key culturing factors for these systems.

This study shows that plant colonization induces antifungal compound production in root-associated microbes, enhancing plant resistance to fungal pathogens.

The paper identifies clavusporins, hydrophobic ribosomal peptides with C-methylations that reduce surface tension and promote Streptomyces development.

The paper identifies NXPE1 as an acetyltransferase that modifies mucin glycans in colonic mucus, showing its role in modulating the mucus barrier against commensal microbes in ulcerative colitis.

The paper identifies a novel selenium-containing antioxidant, ovoselenol, through bioinformatic and biochemical studies of a newly evolved enzyme class involved in selenometabolite biosynthesis.

The paper reclassifies glycopeptide antibiotics as xyclopeptides based on structural and evolutionary analyses of biosynthetic gene clusters.