Multiple Conformations of Gal3 Protein Drive the Galactose Induced Allosteric Activation of the GAL Genetic Switch of Saccharomyces cerevisiae
Rajesh Kumar Kar, Hungyo kharerin, Ranjith Padinhateeri, Jayadeva Bhat
This study identifies a triple mutant of Gal3p that activates the GAL switch only in response to galactose, revealing conformational dynamics critical for allosteric activation.
Journal of Molecular Biology · Jan 1, 2017Peer-reviewedGenetics