SPEF1 mediates assembly of the central pair microtubule complexes in cilia of Tetrahymena.
Mayukh Guha, Krishna Kumar Vasudevan, Yu‐Yang Jiang, Panagiota Louka, Neeraj Sharma, Mireya Parra, Karl F. Lechtreck, Raphaël F.-X. Tomasi, Charles Naim Baroud, Pascale Dupuis‐Williams, Gerard W. Dougherty, Heymut Omran, Courtney Ozzello, Chad G. Pearson, Ewa Joachimiak, , Jacek Gaertig
This study shows that SPEF1 stabilizes central microtubules in Tetrahymena cilia, with defects in its absence affecting ciliary structure and function.
Journal of Cell Science · Sep 14, 2026Peer-reviewedCell Biology